The use of low dose midazolam for the management of spinal anesthesia
Nagahama, H.; Kikuchi, S.; Shimazaki, K.; Tateda, T.; Aoki, T.; Takahashi, K.
Masui. Japanese Journal of Anesthesiology 45(5): 593-598
1996
ISSN/ISBN: 0021-4892 PMID: 8847786 Document Number: 459779
The present study was designed to evaluate the effects of low dose midazolam (MZ) on memories and ease of management of spinal anesthesia. MZ was administered to 103 patients (ASA 1-2), of whom 50 patients were premedicated with atropine sulfate 0.5 mg and pethidine hydrochloride (group P), with 53 patients receiving no premedication (group nP). A double blind randomized trial was conducted with the dose of MZ (0, 0.01, 0.02, 0.04, 0.08 mg cntdot kg-1), and MZ was administered iv to patients just prior to spinal puncture. The short-term and long-term memories were impaired after administration of MZ in both group. But the recovery from impairment of memories was more rapid in the short-term memory than in the long-term memory, suggesting that MZ impairs mainly the acquisition of memories. A dose-dependent decrease in Sp-O-2 was observed in group P. We conclude that MZ is a useful drug to relieve anxiety of patients during surgery, but it accompanies the risk of respiratory depression.