Clinical evaluation of a combination treatment with cefmenoxime and cefsulodin of severe infections in leukemia and related disorders
Tsuda, S.; Nishigaki, H.; Okuda, T.; Horiike, S.; Yokota, S.; Yashige, H.; Taniwaki, M.; Misawa, S.; Takino, T.; Inazawa, J.
Japanese Journal of Antibiotics 41(5): 577-587
1988
ISSN/ISBN: 0368-2781 PMID: 3216480 Document Number: 308674
A combination of cefmenoxime (CMX) and cefsulodin (CFS) which has a broad spectrum on various bacteria including Pseudomonas aeruginosa was evaluated for severe infections associated with hematological malignancies. Seventy-one patients were treated with the combination therapy. Among them, 57 patients were ealuable for the effectiveness. Fourteen patients were not evaluable because 10 patients were subjected to additional therapy such as .gamma.-globulin, interferon, radiation and pulse therapy of a large dose of methylprednisolone, 3 were prophylactically treated and the remaining one was a patient with disseminated bone marrow metastasis of prostatic cancer and not a patient with a hematologic malignancy. Excellent responses were obtained in 24 (42.1%) patients and good response in 12 (21.1%) patients, with a total rate of effectiveness of 63.2%. Three patients who were treated prophylactically and one patient who suffered from prostatic cancer with metastasis to bone marrow, were included in the final evaluation of side effects. Side effects were observed in only one patient (1/61, 1.6%). Mild neutropenia was identified in a patient of 78 years of age in 4 days after the combined regimen was started. Neutropenia disappeared soon after the cessation of the treatment. These results showed that a combination of CMX and CFS was an effective and safe regimen for the treatment of severe infections in patients with hematological disorders.