The protective action of a water poor in calcium on the liver and digestive apparatus of guinea-pigs chronically treated with 9-alpha-fluoro-16-beta-methylprednisolone
Agostini, G.; Martini, P.; Mian, M.; Renzoni, G.
International Journal of Clinical Pharmacology Research 8(Suppl 1): 1-10
1988
ISSN/ISBN: 0251-1649 PMID: 2473040 Document Number: 308652
An evaluation was made of the possibility of exerting a protective action by administering natural water with a very low saline content, equal to 22 mg/l (oligomineral water), during the course of prolonged treatment with 9-alpha-fluoro-16-beta-methylprednisolone. The study was carried out using guinea-pigs (66 animals in all, of both sexes, clinically healthy, and of standard weight), which were divided into four groups which received, respectively: 9-alpha-fluoro-16-beta-methylprednisolone and aqua fontis, 9-alpha-fluoro-16-beta-methylprednisolone and oligomineral water, aqua fontis by itself, and oligomineral water by itself. Examinations carried out after thirty-four days of experimentation showed that the histomorphological damage to the liver and the digestive apparatus caused by the cortisonic therapy appeared to be considerably reduced and possibly eliminated when this therapy was combined with adequate administration of oligomineral water, such as the one considered in the present experiment.