The isolation and subtyping of the human immunodeficiency virus (HIV) from children in Moldova. the evidence for subtype F
Apetrei, C.; Collin, G.; Diculencu, D.; Ajaka, I.L.; Farfara, I.; Pânzaru, C.; Coman, G.; Duca, M.; Brun-Vezinet, F.; Simon, F.
Revista Medico-Chirurgicala a Societatii de Medici Si Naturalisti Din Iasi 99(1-2): 124-128
1995
ISSN/ISBN: 0048-7848 PMID: 9524668 Document Number: 308413
HIV epidemic related to nosocomial transmission in Romanian nursed children represents up to now more than 50% of paediatric AIDS cases in Europe. Although the sources of this epidemic are obscure, HIV-1 subtype F, a minor form in Brasil and Africa, realised a founder effect in this risk group, thus becoming the major form in Romanian epidemic. This study presents the results of the virus isolation from HIV-infected children in Northeast Romania. Heteroduplex mobility assay (HMA) was performed in order to establish HIV-1 viral subtype for 6 isolates. All tested HIV-1 strains were proved to belong to F subtype. So, our study confirm that HIV-1 subtype F is responsible for the epidemic in the risk group of Romanian nosocomially infected children.