Recent advances in L-asparaginase studies
Taguchi, T.
Gan to Kagaku Ryoho. Cancer and ChemoTherapy 15(5): 1815-1825
1988
ISSN/ISBN: 0385-0684 PMID: 3285797 Document Number: 306827
We surveyed the progress of L-asparaginase studies for last ten years or so, on the progress and the present situation for its clinical application. At present, L-asparaginase is recognized as one of basic drugs for improvement of remission induction mainly in infant ALL and is being positively incorporated in the treatment of high-risk diseases such as intractable ALL and the myelogenous recurrence. L-asparaginase, an E. coli-derived protein preparation, has various side effects except bone marrow suppression. Immune responses caused by E. coli-derived protein preparation is accordingly a characteristic side effect of the L-asparaginase. For the purpose of avoiding this side effect, studies on immobilized enzymes and enzyme derivatives devoid of antigenicity are under progress.