The effect of bunazosin hydrochloride on the intraocular pressure and the aqueous humor dynamics of the rabbit eye
Sugiura, Y.; Araie, M.
Nippon Ganka Gakkai Zasshi 92(7): 1202-1207
1988
ISSN/ISBN: 0029-0203 PMID: 2903620 Document Number: 306029
The effects of bunazosin hydrochloride, a new selective .alpha.1 adrenergic antagonist, on the intraocular pressure (IOP) and the aqueous humor dynamics were studied in the albino rabbit eye. A single instillation of 0.1% bunazosin hydrochloride (50 ul) significantly lowered the IOP for 3 hours; the maximum effect was 6.0 .+-. 1.5 mmHg (Mean .+-. SE, n = 6) as compared with the fellow control eye at one hour. The aqueous flow rate remained unaltered after repeated instillation of 0.1% bunazosin hydrochloride at an interval of one hour, although the repeated instillation of the drug significantly reduced the IOP throughout the experimental period; the average aqueous flow rate during the experiment was 3.94 .+-. 0.35 ul/min (Mean .+-. SE, n = 7) for the treated eye, and 3.75 .+-. 0.27 ul/min for the control eye. The aqueous flow rate, determined every 20 minutes, showed no significant difference between the treated and the fellow control eye at any time point. It is suggested that the ocular hypotensive effect of bunazosin hydrochloride may be at least partly due to an increase in the uveoscleral flow.