3-Ethyl-8-methyl-1,3,8-triazabicyclo (4,4,0) decan-2-one: a new antifilarial agent
Saxena, R.; Iyer, R.N.; Anand, N.; Chatterjee, R.K.; Sen, A.B.
Journal of Pharmacy and Pharmacology 22(4): 306-307
1970
ISSN/ISBN: 0022-3573 PMID: 4392575 Document Number: 30488
An analogue of diethylcarbamazine, 3-ethyl-8- methyl-l, 3, 8-triazabicyclo decan-2-one, was found to be significantly more effective than diethyl-carbamazine in reducing microfilarial counts in cotton-rats infected with Litomosoides carinii and its activity seemed to persist longer. The new compound appeared to be less toxic than diethylcarba-mazine.
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