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Relation between the rate of ubiquinone biosynthesis and the activity of cholesterogenesis in the rat liver and kidney

Fedurov, V.V.; Belomar, L.B.

Voprosy Meditsinskoi Khimii 33(5): 134-139

1987

ISSN/ISBN: 0042-8809
PMID: 3686893
Document Number: 303359
Incorporation of I-14C-acetate into ubiquinone and sterols was studied in liver and kidney tissues of rats after intragastric administration of cholesterol as well as in the animals kept within 2 days on a diet containing cholestyramine or after the bile duct ligation. The rate of incorporation of the labelled compounds into liver sterols was distinctly decreased within the night under the influence of cholesterol-containing diet, while the higher rate of incorporation of the labelled compounds was found in liver tissue of rats, treated with cholestyramine or after bile duct ligation as well as in control animals during night. Regression-correlation analysis demonstrated the positive linear correlation between rates of incorporation of the labelled compounds into ubiquinone and sterols in liver tissue of all the rat group studied. The corresponding correlation was less distinct in kidney tissue.

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Donchenko, G.V.; Metal'nikova, N.P.; Palivoda, O.M. 1985: The role of vitamin e in the biosynthesis of the isoprenoid region of the ubiquinone molecule in the rat liver Ukrainskii Biokhimicheskii Zhurnal 57(1): 47-52
Szkopińska, A. 2000: Ubiquinone. Biosynthesis of quinone ring and its isoprenoid side chain. Intracellular localization Acta Biochimica Polonica 47(2): 469-480
Williams, M.T.; Gaylor, J.L.; Morris, H.P. 1977: Investigation of the rate-determining microsomal reaction of cholesterol biosynthesis from lanosterol in Morris hepatomas and liver Cancer Research 37(5): 1377-1383
Timoshchuk, S.V.; Vavilova, H.L.; Strutyns'ka, N.A.; Kuchmenko, O.B.; Petukhov, D.M.; Donchenko, H.V.; Sahach, V.F. 2008: In vivo effect of precursors of ubiquinone biosynthesis on sensitivity of mitochondrial permeability transition pore in the heart of old rats Fiziolohichnyi Zhurnal 54(3): 3-9
Deev, L.I.; Topchishvili, G.I.; Akhalaia, M.I.; Platonov, A.G. 1985: Effect of x-ray irradiation on the activity of key enzymes in heme biosynthesis and breakdown in the rat liver Biulleten' Eksperimental'noi Biologii i Meditsiny 99(6): 681-683
Duca, S.; Ghilardi, F.; Gillio, S.; Liboni, W.; Rivadossi, G.A. 1978: Changes in the rate of carotid blood flow in relation to cardiac activity Minerva Cardioangiologica 26(12): 825-828
Fomenko, B.S.; Zaslavskiĭ, I.A. 1974: Polarographic determination of ubiquinone in rat liver Voprosy Meditsinskoi Khimii 20(5): 554-558
Poliakova, E.D.; Dizhe, E.B.; Klimova, T.A.; Denisenko, T.V.; Vasil'eva, L.E. 1981: Activities of 3-hydroxy-3-methylglutaryl-CoA reductase and acetyl-CoA carboxylase and rate of biosynthesis of mevalonic acid, squalene, sterols and fatty acids from [1-14C]acetyl-CoA and [2-14C]malonyl-CoA in rat liver: changes induced by daily rhythm Biokhimiia 46(1): 126-139
Fedurov, V.V.; Kuz'menko, I.V. 1971: Content of ubiquinone (coenzyme Q) in the regenerating liver of albino rats Biulleten' Eksperimental'noi Biologii i Meditsiny 72(9): 47-49
Fedurov, V.V. 1980: Activation of 14C-n-hydroxybenzoate and 2-14C-mevalonate incorporation into ubiquinone in regenerating rat liver Voprosy Meditsinskoi Khimii 26(6): 759-763
Kulagina, T.P.; Kolomiĭtseva, I.K.; Obol'nikova, E.A.; Samokhvalov, G.I.; Kuzin, A.M. 1992: Effects of ubiquinone-9 on lipids of nuclei and chromatin of the rat liver under continuous irradiation Biulleten' Eksperimental'noi Biologii i Meditsiny 113(3): 253-254
Dushkin, M.I.; Ivanova, M.V. 1992: Effect of ketoconazole on the activity of key enzymes of biosynthesis of cholesterol and its esters in the liver of rats maintained on a cholesterol-enriched diet Ukrainskii Biokhimicheskii Zhurnal 64(3): 73-76
Marchi, S.; Polloni, A.; Costa, F.; Bellini, M.; Bonifazi, V.; Tumino, E.; Grassi, B.; Romano, M.R.; De Bartolo, G.; Bertelli, A. 1990: Liver triglyceride accumulation after chronic ethanol administration: a possible protective role of metadoxina and ubiquinone International Journal of Tissue Reactions 12(4): 247-250
Che, M.L. 1990: The significance of HBsAg and HBcAg levels in the liver and their relation to histopathologic activity Zhonghua Nei Ke Za Zhi 29(2): 102-104; 127
Wesemann, W.; Ekenna, O. 1982: Effect of 1-aminoadamantanes on the MAO activity in brain, liver, and kidney of the rat Arzneimittel-Forschung 32(10): 1241-1243
Gelli, G.; Pogliani, M.; Giusti, C. 1970: The rate of aortic pulse propagation studied in relation to heart rate Bollettino Della Societa Italiana di Cardiologia 15(4): 297-301
Tarnowski, R. 1973: Effect of 17-estradiol on the activity of aspartate carbamoyl-transferase (EC 2.1.3.2.) in the liver, kidney and uterus of the rat Ginekologia Polska 44(9): 985-991
Alvarez, F.J.; Dueñas, A.; García Roldán, J.L.; Carvajal, A.; Velasco Martín, A. 1983: Effect of etomidate sulfate on the oxidative activity of rat liver, kidney and heart in vitro Archivos de Farmacologia y Toxicologia 9(3): 269-274
Zhao, L.-s.; Liao, Y.-h.; Xiang, G.-d.; Wang, M.; Le, L.; Zhou, Z.-h.; Lin, X.; Sun, H.-l. 2008: The relation between positive rate of autoantibodies against beta1 and M2-adrenergic receptors and urinary albumin excretion rate in the type 2 diabetes mellitus with refractory hypertension Zhonghua Xin Xue Guan Bing Za Zhi 36(6): 527-530
Iaverbaum, P.M.; Tsverbaum, E.A.; Kas'ianova, T.G. 1972: Lactate dehydrogenase activity of the liver, kidney, muscle and serum in experimental lead poisoning Gigiena Truda i Professional'nye Zabolevaniya (5): 54-55