Complex pathogenetic therapy of experimental botulism
Kryzhanovskiĭ, G.N.; Morrison, V.V.
Biulleten' Eksperimental'noi Biologii i Meditsiny 104(11): 543-545
1987
ISSN/ISBN: 0365-9615 PMID: 2823931 Document Number: 303280
The study of survival and life span of mice and white rats upon the administration of LD50 of the toxin has shown that an antihypoxic agent--gutimine (50-200 mg/kg)--had a protecting effect in type C botulinum intoxication. A combined use of gutimine and 4-aminopyridine (1-5 mg/kg), facilitating a transmitter release in synapses, had a more marked protecting effect in botulinum intoxication. Due to the potentiation of the drugs effect during their combined application, the doses of each drug in the combination could be reduced.