Immunopotentiating effects of oxalysine
Li, X.Y.; Tong, L.M.; Jin, Y.F.; Cao, C.Y.; Liang, H.Z.; Wang, J.F.; Zhu, P.P.; Wang, J.Y.
Zhongguo Yao Li Xue Bao 8(2): 173-177
1987
ISSN/ISBN: 0253-9756 PMID: 2959008 Document Number: 303198
L-4-Oxalysine is an antibiotic agent isolated from a new species of Streptomyces roseoviridofuscus in China. It inhibited the growth of several kinds of animal transplanted tumors and protected liver injuries from CCl4 intoxications. Clinical trials showed improvement of liver function as well as liver blood flow in patients of chronic viral hepatitis. Oxalysine 100 mg/kg ip or ig administration to C57/BL mice caused a marked increase of spleen plaque forming cells as well as serum hemolysin and IgG levels. Serum complement C3 is also increased. Oxalysine 50 and 100 mg/kg ip for 3 d or 100 mg/kg ig for 5 d promoted the incorporation rate of [3H]TdR into spleen lymphocytes but showed no direct stimulating effect on lymphocyte blastogenesis in vitro. Oxalysine also elevated the SRBC induced delayed-type hypersensitivity on ICR mice, but had no effect on the phagocytic activity of macorophages. It is therefore considered that oxalysine has the ability of potentiating both humoral and cell mediated immunological responses, which is benefit in ameliorating the immunodeficient condition in patients suffered with cancer or chronic viral hepatitis.