Effect of oxalysine on plasma fibrinogen content in tumor-bearing mice
Yue, X.F.; Wu, F.G.; Xu, B.
Zhongguo Yao Li Xue Bao 3(2): 124-128
1982
ISSN/ISBN: 0253-9756 PMID: 6214145 Document Number: 193204
The plasma fibrinogen level was determined by Astrup's method in tumor-bearing mice. Plasma fibrinogen was elevated significantly in mice bearing B-22 fibrinogen in tumor tissue of B-22 was significantly higher than that of Ehrlich carcinoma cells (P < 0.01). Oxalysine, a new antitumor antibiotic, markedly inhibited the solid forms of mouse tumor, but not the ascites forms. Oxalysine 0.20 g/kg markedly reduced the fibrinogen content in mice bearing B-22 to the normal level. Lysine antagonized the fibrinogen-lowering effect of oxalysine in mice bearing solid tumor B-22. The fibrin lattice-work probably plays an important role in the growth of solid tumor; the antitumor activity of oxalysine may be associated with its inhibiting action on fibrinogen synthesis.