Disulfiram inhibition of aldehyde reductase from the rat liver
Pozniakova, T.N.; Konoplitskaia, K.L.; Zakashun, T.E.; Khustochka, L.N.
Ukrainskii Biokhimicheskii Zhurnal 59(3): 19-23
1987
ISSN/ISBN: 0201-8470 PMID: 3603729 Document Number: 302501
Disulphiram (tetraethylthiuram disulphide teturam, antabus), the known antialcoholic preparation, is studied for its effect on the aldehyde reductase activity (EC 1.1.1.1) in the rats' liver. Apparent Km and V are calculated for acetylaldehyde and NADH as well as Ki of disulphiram relative to the substrate and cofactor of the enzyme. The obtained data permit considering disulphiram a high-specific inhibitor of aldehyde reductase in rats' liver.