A collaborative exercise on cytogenetic dosimetry for simulated whole and partial body accidental irradiation
Lloyd, D.C.; Edwards, A.A.; Prosser, J.S.; Barjaktarovic, N.; Brown, J.K.; Horvat, D.; Ismail, S.R.; Köteles, G.J.; Almassy, Z.; Krepinsky, A.
Mutation Research 179(2): 197-208
1987
ISSN/ISBN: 0027-5107 PMID: 3302692 Document Number: 302500
An experiment sponsored by the International Atomic Energy Agency was undertaken to compare dose estimation by cytogenetic analysis on aliquots of samples of irradiated blood sent by air to participating laboratories. Accidental acute whole-body irradiations to 0.7 and 2.34 Gy and half-body irradiations to 3.5 Gy were stimulated with X- and .gamma.-rays. For the partial irradiations the size of the irradiated fraction and its dose were estimated by the Qdr and contaminated Poisson techniques. Each laboratory's in vitro dose-response data were fitted to the quadratic model by the iteratively reweighted least squares method. Interlaboratory variations in the dose-response curves, and in the aberration yields and dose estimates for the stimulated accidents were noted. However, in general, most participants consistently obtained results acceptably close to the true values.