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Pharmacokinetic perfusion model of presystemic metabolism with renal clearance

Huang, S.K.; Liu, X.D.

Zhongguo Yao Li Xue Bao 8(2): 180-184

1987

ISSN/ISBN: 0253-9756
PMID: 2959010
Document Number: 301823
A pharmacokinetic perfusion model of presystemic metabolism with renal clearance (RPPP model) has been developed to describe the time course of drugs that are subject to preabsorptive, intestinal epithelial, hepatic first-pass metabolism and renal clearance. Equations are derived and solved using statistic moment analysis to estimate the metabolized fractions of the administered dose in each of the three sites. The model is compared with a pharmacokinetic perfusion model of presystemic metabolism without consideration of renal clearance.

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