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Side effects of nalidixic acid in a patient with severe renal failure. Clinical study and proposal of a pharmacokinetic model

Mobbs, J.P.; Balant, L.; Revillard, C.; Favre, H.

Schweizerische Medizinische Wochenschrift 107(9): 300-306

1977

ISSN/ISBN: 0036-7672
PMID: 847456
Document Number: 112513
Side effects due to ingestion of nalidixic acid in a 46 year old patient with phenacetine-induced interstitial nephritis and severe renal failure are reported. This observation underlines the point that, besides the direct neurotoxic effect of nalidixic acid, disturbance of the acid-basic equilibrium could be seen in patients with renal failure in particular. A hypothetical pharmacokinetic model suggests that two metabolites of nalidixic acid could provide enough hydrogen ion to induce acidosis in cases of renal failure.

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