Pharmacokinetic model of presystemic metabolism
Colburn, W.A.; Gibaldi, M.
Drug Metabolism and Disposition the Biological Fate of Chemicals 6(2): 193-196
1978
ISSN/ISBN: 0090-9556 PMID: 26536 Document Number: 132774
A pharmacokinetic perfusion model is presented that describes the disposition of drugs that are subject to both first-pass hepatic and intestinal epithelial metabolism. Equations are developed to estimate hepatic and intestinal epithelial clearances by determining drug concentrations as a function of time in both portal and peripheral vein blood after oral and iv administration, and by determining or estimating the flow rate of blood perfusing the gastrointestinal tissues. A method that can be used, under the stated conditions, to approximate the systemic availability after oral administration of drugs subject to presystemic metabolism is also developed.