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The effect of ranitidine on oesophageal motility

Naess, F.; Nygaard, K.; Haffner, J.

Scandinavian Journal of Gastroenterology 22(9): 1064-1066

1987

ISSN/ISBN: 0036-5521
PMID: 3321394
Document Number: 299795
Ranitidine is used to treat symptomatic oesophageal reflux; its effect is probably to a great extent due to reduced gastric secretion. Whether it also affects oesophageal motility is a matter of controversy. In a randomized double-blind study oesophageal motility was recorded in 21 healthy individuals after 3 doses of 150 mg ranitidine or placebo given over 36 h. Ranitidine increased the pressure in the lower oesophageal sphincter from 14 to 18 mmHg (p = 0.05) but otherwise did not influence oesophageal motility.

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