Diagnosis of mosaic forms of karyotype anomalies in clinical cytogenetic research
Kuleshov, N.P.; Simonian, I.V.
Tsitologiia i Genetika 21(1): 60-63
1987
ISSN/ISBN: 0564-3783 PMID: 3551263 Document Number: 298638
Mosaicism cases have been statistically analyzed with the aim to develop a general scheme of the cytogenetic study. Using the Bernoulli formula it is shown that when P = 0.95 and proportion of clones is 10:90% and more 29 cells should be initially analyzed. If all the cells are of the same chromosomal constitution (m = 0) the mosaicism is rejected. Mosaicism is highly probable when m = 4 and more among n = 29. When m = 1, 2 or 3 the number of cells should be increased to 44 in accordance with calculations by the formula: 1--Cnm.pm.(1--p)n-m = P.