Effect of isoflurane anesthesia on glucose metabolism
Tsubo, T.; Iida, T.; Kudo, T.; Kudo, M.; Matsuki, A.; Oyama, T.
Masui. Japanese Journal of Anesthesiology 36(5): 732-736
1987
ISSN/ISBN: 0021-4892 PMID: 3656643 Document Number: 298474
The effects of isoflurane and halothane anesthesia and surgery on glucose metabolism were studied in twenty patients who underwent transabdominal gynecological operations. Ten patients underwent isoflurane anesthesia and ten patients received halothane anesthesia. Plasma levels of insulin, glucagon, human growth hormone, cortisol, epinephrine, nor-epinephrine, dopamine, blood glucose and free fatty acid were measured as indices of glucose metabolism. The changes in endocrine response to isoflurane anesthesia were compared with those of halothane anesthesia. No significant effect of isoflurane anesthesa alone for 30 min on endocrine function was found as in halothane anesthesia. A significant increase in plasma levels of growth hormone, cortisol, epinephrine, norepinephrine, dopamine, blood glucose and free fatty acid was observed in both anesthetic groups during the operation. However, no significant change was observed in plasma levels of insulin and glucagon. Plasma concentrations of dopamine were higher in isoflurane anesthesia group compared with those in halothane anesthesia group 60 min after the start of the operation. We speculate that isoflurane would cause almost the same effects as halothane on glucose metabolism.