Neuroendocrine response in surgery: comparison between inhalation anesthesia (isoflurane) and intravenous anesthesia (propofol)
Filippucci, G.; Raccanelli, L.; Parodi, A.; Salmeri, D.; Bindi, M.L.; Celentano, R.; Gamaleri, F.; Boccignone, E.
Minerva Anestesiologica 60(11): 675-680
1994
ISSN/ISBN: 0375-9393 PMID: 7761017 Document Number: 437309
The objectives of the study: 1) comparison between the two anesthesiological techniques both of which were applied to the various surgical groups (patients undergoing emergency surgery for abdominal pathologies and patients undergoing bone marrow biopsy); 2) a comparison between pre- and intraoperative stress levels. The experimental design consists of a comparative survey aimed at ascertaining the existence of statistically significant differences in pre- and intraoperative hormone levels (objective 1) and differences in hormone profiles depending on the anesthesiological technique used (objective 2). Patients were artificially ventilated; intraoperative monitoring included: automatic non-invasive AP every 3 minutes; cardiac monitoring; ETCO2; SaO2; all patients showed a normal postoperative evolution. A total of 30 patients were included in the study (mean age 34 years; ASA 1-3) 14 of which underwent bone marrow biopsy and 16 emergency surgery for abdominal pathologies; patients with hormonal pathologies or receiving treatment with drugs capable of influencing hormone response were excluded from the study.