Liver cytosolic protein-bound folates in phenobarbitone-treated rats
Formiggini, G.; Sassi, S.; Bovina, C.; Marchetti, M.
International Journal for Vitamin and Nutrition Research. Internationale Zeitschrift für Vitamin- und Ernahrungsforschung. Journal International de Vitaminologie et de Nutrition 57(4): 405-409
1987
ISSN/ISBN: 0300-9831 PMID: 2831173 Document Number: 298437
The effect of acute phenobarbitone treatment on the distribution of endogenous bound folates in three specific cytosolic folate-binding proteins (FBP-C), has been studied in rat liver. The bound folate amount shows no difference between treated and control rats. As it is well known that FBP's preferentially bind longer-chain polyglutamates, the content of which is markedly lower in phenobarbitone-treated rat liver, it might be suggested that shorter chain folates also bind to FBP's in these animals.