Appearance of C-reactive protein (CRP) in serum and liver cytosol of cadmium-treated rats
Agrawal, A.; Bhattacharya, S.
Indian Journal of Experimental Biology 27(12): 1024-1027
1989
ISSN/ISBN: 0019-5189 PMID: 2633960 Document Number: 344756
The possibility of stimulation of C-reactive protein (CRP) due to inflammation and necrosis caused by cadmium was investigated. Cadmium injection (less than 3 mg/kg body weight) in white rat was found to be associated with the appearance of CRP in liver cytosol after 8 hr and in serum after 18 hr of injection. Although, no definite dose-response relationship was found, yet CRP level was elevated drastically, varying from 1-4 mg/g wet weight liver and 0.3-0.7 mg/ml serum. CRP-positive serum from Cd-treated rats precipitated with normal rat serum on agarose-covered slides in the presence of 1 mM CaCl2. Evidences for raised level of CRP indicates acute tissue damage in the animal.