Gastrectomized patients are in a state of chronic protein malnutrition analyses of 23 amino acids
Saito, A.; Noguchi, Y.; Yoshikawa, T.; Doi, C.; Fukuzawa, K.; Matsumoto, A.; Ito, T.; Tsuburaya, A.; Nagahara, N.
Hepato-Gastroenterology 48(38): 585-589
2001
ISSN/ISBN: 0172-6390 PMID: 11379360 Document Number: 298
Background and aims: Malnutrition is one of the major postoperative complications of radical subtotal or total gastrectomy for gastric cancer. This study was conducted to clarify the nutritional consequences of radical gastrectomy with respect to protein metabolism. Methodology: To evaluate the nutritional status and the abnormalities in protein metabolism in such cases, serum concentrations of 23 amino acids were measured by HPLC in 40 patients [Japan] who underwent either subtotal (n=20) or total (n=20) gastrectomy more than 6 months prior to this analysis. Results: Serum concentrations of total amino acids and nonessential amino acids were the same between gastrectomized patients and healthy controls (n=50). However, concentrations of essential amino acids, essential amino acid/nonessential amino acid and branched chain amino acid/total amino acid ratios were significantly lower in patient groups than in normal controls. Each essential amino acid was decreased and concentrations of glutamate and citrulline were increased in both patient groups compared with controls. The major differences between patients with subtotal and total gastrectomies included an increased ornithine and a decreased arginine concentration in patients with subtotal gastrectomy. Conclusions: These changes suggest that malabsorption of protein from the intestinal tract causes persistent proteolysis in the skeletal muscle for long periods of time after surgery in these patients and that changes in ornithine and citrulline levels may reflect more severe alterations in those with total gastrectomy.
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