Effect of oxaloacetic acid on hydrogen-calcium metabolism in mitochondria
Asrarov, M.I.; Gagel'gans, A.I.; Tashmukhamedov, B.A.
Biofizika 32(3): 454-457
1987
ISSN/ISBN: 0006-3029 PMID: 3620523 Document Number: 297137
It has been shown by using o-phthalic acid--a concurrent inhibitor of the transport of oxalacetic acid in mitochondria that the effect of the latter on the mechanism of 2H+/Ca2+-metabolism is realized at the inner side of the inner mitochondrial membrane. Oxalacetic acid was shown to induce not only the release of Ca2+ ions but also those of strontium and manganese accumulated in the mitochondria (100-150 nmol/mg of protein). Mechanism of the effect of oxalacetic acid on permeability of the mitochondria membranes are discussed.