The effect of sodium salicylate on utilization of alpha-ketoglutarate in the rat liver mitochondria, in relation to calcium content in the medium
Poćwiardowska, E.; Korolkiewicz, Z.
Acta Physiologica Polonica 26(6): 563-567
1975
ISSN/ISBN: 0044-6033 PMID: 1108595 Document Number: 87665
The amount of .alpha.-ketoglutarate utilized by the rat liver mitochondria by increasing sodium salicylate concentrations in the incubation medium without Ca, were compared with those in the presence of Ca++. Presence of Ca++ in the incubation medium abolished the stimulatory effect of sodium salicylate on .alpha.-ketoglutarate utilization. This may result from the ability of salicylates to chelate Ca ions. Pyrogen-standard Escherichia coli, in vitro did not show antagonistic action to salicylate or Ca present in the incubation medium.