The effects of antipyretics on metabolic processes in rat liver mitochondria. Part II. The action of sodium salicylate, and pyrazolones on oxidation of alpha-ketoglutarate
Poćwiardowska, E.
Polish Journal of Pharmacology and Pharmacy 28(3): 227-231
1976
ISSN/ISBN: 0301-0244 PMID: 951304 Document Number: 105348
The effect of sodium salicylate (SS), phenazone (Ph) and amiphenazone (APh) on the uptake of .alpha.-ketoglutarate (.alpha.-KG) by the rat liver mitochondria was studied in vitro. The investigated antipyretics inhibited the uptake of .alpha.-KG in the state 3 of respiration and significantly increased it in state 4. .alpha.-KG taken up by the mitochondrial preparations in respiratory state 4 is not utilized in the oxidative processes of the respiratory chain.