Structural determination of yejuhua lactone, isolated from Chrysanthemum indicum L
Chen, Z.N.; Xu, P.J.
Yao Xue Xue Bao 22(1): 67-69
1987
ISSN/ISBN: 0513-4870 PMID: 3604697 Document Number: 296639
Yejuhua lactone (C15H18O4) was isolated in 1962 from yejuhua (the flowers of Chrysanthemum indicum L.), a commonly known Chinese medicinal herb. It was considered as a new sesquiterpene lactone with guainolide type whose partial structure was postulated in the following year, but the full structure remains unsolved. In this paper, the early empirical formula and some experimental results have been revised. On the basis of our studies, it is shown that the compound is a diguainolide with the formula of C32H40O8. By comparison of spectral data (IR, 1H NMR and 13C NMR), yejuhua lactone is proved to be the same compound as handelin the structure of which was elucidated by V.A. Tarasov et al in 1976.