Determination of the concentration of immunoglobulins and other proteins in bronchoalveolar fluid of patients with various types of pulmonary pathology
Titanian, A.S.; Selitskaia, R.P.; Kim, A.C.
Terapevticheskii Arkhiv 59(12): 48-51
1987
ISSN/ISBN: 0040-3660 PMID: 2451861 Document Number: 296565
The levels of immunoglobulins and other proteins (alpha 2-MG, alpha 1-AT, C3, albumin, transferrin and lactoferrin) were studied in the BAL of 60 patients with different types of pulmonary tuberculosis, 4 patients with sarcoidosis and 7 CNPD patients. The level of most proteins in BAL of the examinees was higher than that reported for healthy subjects. The highest protein levels were noted in CNPD and sarcoidosis patients. The diagnostic importance of the level of alpha 2-MG was established for sarcoidosis. 27 paired BAL-serum specimens from the same patients with pulmonary tuberculosis were investigated for analysis of the mechanisms of protein appearance in BAL. The protein/albumin ratio for most proteins was higher in BAL than in the respective serum. A relatively high level of proteins in the patients' BAL was probably determined by the activation of their local synthesis.