Ifosfamide treatment for children with malignant tumor
Muchi, H.; Taniguchi, Y.; Makino, S.
Gan to Kagaku Ryoho. Cancer and ChemoTherapy 14(12): 3291-3294
1987
ISSN/ISBN: 0385-0684 PMID: 3688893 Document Number: 296414
Seven drugs were administered to nude mice with transplanted TNB9 neuroblastoma. DTIC, cyclophosphamide and ifosfamide were the first-line drugs against TNB9. Chemotherapy including ifosfamide was effective to three of six children with malignant solid tumor resistant to cisplatin and/or cyclophosphamide. Two of the patients who were pretreated with radiotherapy were found to have hemorrhagic cystitis after ifosfamide administration. It therefore seems that chemotherapy with ifosfamide should be withheld after radiotherapy.