Prognostic value of flow cytometrical DNA measurements in stage I-II endometrial carcinoma: correlations with steroid receptor concentration, tumor myometrial invasion, and degree of differentiation
Lindahl, B.; Alm, P.; Fernö, M.; Killander, D.; Långström, E.; Norgren, A.; Trope, C.
Anticancer Research 7(4b): 791-797
1987
ISSN/ISBN: 0250-7005 PMID: 3674764 Document Number: 296415
The prognostic value of flow cytometric DNA measurement of individual tumor cells was studied in 166 patients with endometrial carcinoma stage I-II. Follow-up time was 1-46 months and 110 patients were followed for more than 2 years. Three different ways of estimating DNA ploidy were evaluated, and the use of normal endometria in defining diploidy was considered the best. DNA-ploidy had a much more marked prognostic value in terms of 2-year recurrence-free survival than other known prognostic parameters, such as degree of differentiation, range of myometrial invasion and estradiol and progesterone receptor concentrations. The proliferative activity as determined by DNA-flowcytometrical analysis was not correlated with prognosis.