Progress in the understanding of inducible models of chronic arthritis
Breedveld, F.C.; Trentham, D.E.
Rheumatic Diseases Clinics of North America 13(3): 531-544
1987
ISSN/ISBN: 0889-857X PMID: 3324204 Document Number: 294540
Definitive information regarding the etiology of most rheumatic syndromes is not available, but studies of several inducible models of chronic arthritis have helped to identify pathogenetic mechanisms in human inflammatory arthritis. Animal models offer an opportunity to analyze morphologic and biochemical changes occurring during the course of an arthritis, probe the role of genetics, and predict the effects of therapeutic interventions in the human disease. This article describes some contributions obtained from animal studies.