Research Progress of Experimental Animal Models of Avascular Necrosis of Femoral Head
Yu, K.; Tan, H.; Xu, Y.
Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi 29(12): 1564-1569
2015
ISSN/ISBN: 1002-1892 PMID: 27089555 Document Number: 681742
To summarize the current researches and progress on experimental animal models of avascular necrosis of the femoral head. Domestic and internation literature concerning experimental animal models of avascular necrosis of the femoral head was reviewed and analyzed. The methods to prepare the experimental animal models of avascular necrosis of the femoral head can be mainly concluded as traumatic methods (including surgical, physical, and chemical insult), and non-traumatic methods (including steroid, lipopolysaccharide, steroid combined with lipopolysaccharide, steroid combined with horse serum, etc). Each method has both merits and demerits, yet no ideal methods have been developed. There are many methods to prepare the experimental animal models of avascular necrosis of the femoral head, but proper model should be selected based on the aim of research. The establishment of ideal experimental animal models needs further research in future.