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Biologic characterization of canine melanoma cell lines

Wolfe, L.G.; Oliver, J.L.; Smith, B.B.; Toivio-Kinnucan, M.A.; Powers, R.D.; Brawner, W.R.; Henderson, R.A.; Hankes, G.H.

American Journal of Veterinary Research 48(11): 1642-1648

1987

ISSN/ISBN: 0002-9645
PMID: 3434911
Document Number: 293758
Eight canine melanoma cell lines were established from tissues from 6 dogs with spontaneous primary or metastatic melanomas. Cell lines were characterized for morphologic features and growth patterns on plastic, pigmentation, ultrastructure, cloning efficiency in soft agar, and tumorigenicity in nude mice. Biologic properties of cell lines were distinct and preserved during 40 to 120 passages in vitro. All cell lines were clonogenic and tumorigenic.

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