Filler-controlled release from suspension matrices (laminates)
Lippold, B.C.; Kurka, P.
Die Pharmazie 42(11): 729-731
1987
ISSN/ISBN: 0031-7144 PMID: 3438337 Document Number: 293167
The release from a matrix (polyethylenmineral oilgel, Plastibase) with drug (bupranolol) in suspension can be controlled by a controlling layer of the same material which is saturated with the drug. Thus, after a burst period zero order release is reached from the laminate, before square root t-kinetics predominate. The duration of constant release may be extended with fillers in the controlling layer (glass beads, d less than 20 microns). Increasing the thickness of the controlling layer increases both duration of constant release and time to reach it, the latter to a lower extent.