In vivo-in vitro correlation of salbutamol release from a controlled release osmotic pump delivery system
Civiale, C.; Ritschel, W.A.; Shiu, G.K.; Aiache, J.M.; Beyssac, E.
Methods and Findings in Experimental and Clinical Pharmacology 13(7): 491-498
1991
ISSN/ISBN: 0379-0355 PMID: 1784147 Document Number: 384579
The drug release of salbutamol from a controlled release (osmotic pump) tablet was determined in vitro by four different dissolution apparatuses. From published in vivo data, percent of drug absorbed and percent of drug released in vivo were estimated. The highest correlation was obtained between percentage released in vitro versus percentage released in vivo using polynomial regression.