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Unitary-core osmotic pump tablet for controlled release of water-insoluble drug

Liu, L.-x.; Xu, Q.; Khang, G.; Rhee, J.-m.; Lee, H.-b.

Yao Xue Xue Bao 38(12): 966-967

2003

ISSN/ISBN: 0513-4870
PMID: 15040097
Document Number: 556038
To study unitary-core osmotic pump tablet for delivering water-insoluble drug for 24 hours. Unitary-core osmotic pump tablet was prepared using nifedipine as the model drug. The effects of various core formulation variables on drug release were studied. Polyethylene oxide and potassium chloride have comparable positive effects on drug release, whereas, nifedipine has markedly negative effect on drug release. Unitary-core osmotic pump tablet is very easy in preparation and it can deliver water-insoluble drug in substantially constant rate for 24 hours.

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