Antagonism by naloxone of anti-tremorine effect of bromocriptine in mice
Shukla, V.K.; Garg, S.K.; Kulkarni, S.K.
Methods and Findings in Experimental and Clinical Pharmacology 9(5): 303-306
1987
ISSN/ISBN: 0379-0355 PMID: 3613759 Document Number: 292597
Effects of the opioid antagonist naloxone (10 mg/kg) and its interaction with anticholinergic (scopolamine) and dopaminergic (bromocriptine) agents against tremorine-induced tremors was studied. Naloxone (10 mg/kg) per se gave significant protection and significantly potentiated the protective effect of scopolamine against tremorine-induced tremors at 5 min only. When naloxone and subeffective dose of bromocriptine (2 mg/kg) were administered simultaneously, instead of protection, an enhancement of tremorogenic activity was seen. Although the exact mechanism of this drug interaction is far from clear, a multireceptor involvement (i.e. opioid, dopaminergic and cholinergic type) in the modulation of tremorine-induced tremors in mice has been speculated.