Clinical observations on the antagonism of immobilon by naloxone in dogs
Dodman, N.H.; Waterman, A.E.
Veterinary Record 103(15): 334-335
1978
ISSN/ISBN: 0042-4900 PMID: 726197 Document Number: 130235
The efficacy of naloxone hydrochloride in reversing etorphine (Immobilon) anaesthesia was evaluated in 14 dogs. Although a dose rate of 0.02 mg per kg body weight briefly reversed the respiratory and cardiovascular depression, a dose of at least 0.6 mg per kg body weight was required before full recovery of consciousness occurred. The action of naloxone was relatively short liver, and relapse tended to occur after 10 to 15 minutes. The implications of these findings are discussed in relation to the use of naloxone in the event of accidental self-administration of Immobilon in man.