Edrophonium for the antagonism of neuromuscular blockade in dogs
Clutton, R.E.
Veterinary Record 134(26): 674-678
1994
ISSN/ISBN: 0042-4900 PMID: 7941276 Document Number: 437154
Neuromuscular, electrocardiographic and autonomic nervous changes were studied when endrophonium and 4 combinations of edrophonium and atropine were used to antagonise veruconium-induced neuromuscular blockade in 87 dogs anaesthetised with halothane. Edrophonium (500 micro g/kg bodyweight) was given alone, or with atropine (40 micro g/kg) or one minute after a dose of 600 micro g of atropine, and a lower dose of edrophonium (250 micro g/kg) was used with high (40 micro g/kg) and low (20 micro g/kg) doses of atropine. The neuromuscular blockade was antagonised when some recovery was present. The reversal was rapid and complete in 75 cases, but the remaining 12 dogs which received the low dose of edrophonium required a second injection. Trials with the high dose of edrophonium alone were discontinued because cardiac arrest occurred in one dog and bronchosecretion with profuse salivation in another. The heart rate increased with the low dose of edrophonium and the high dose of atropine, and increased and then decreased when edrophonium was followed by 600 micro g of atropine. The heart rate was stable when the high and low doses of atropine and edrophonium were matched. All the treatments caused atrioventricular blockade. Non-cardiac autonomic changes (salivation and bronchosecretion) occurred in only 2 of the 87 dogs.