Antagonism of the gastrointestinal ulcerogenic effect of some nonsteroidal anti-inflammatory agents by sodium salicylate
Ezer, E.; Palosi, E.; Hajós, G.; Szporny, L.
Journal of Pharmacy and Pharmacology 28(8): 655-656
1976
ISSN/ISBN: 0022-3573 PMID: 11321 Document Number: 109632
The ulcerogenic effect of non-steroidal anti-inflammatory drugs (indomethacin, nifluminic acid, phenylbutazone and acetylsalicylic acid) on the gut, and the antagonism of this effect by salicylate, was studied in Wistar rats. Possibly, certain types of prostaglandins play a role in maintaining the integrity of the gut and aspirin-like drugs separately induce ulcers by unbalancing prostaglandin equilibrium. When salicylic acid and aspirin-like drugs are combined, disturbances in the equilibrium are not strong enough to cause damage to the gut wall.