Dose-related effect of dexamethasone on the poly- (ADP ribose) synthesis of human lymphocytes
Sagaster, P.; Dolejs, I.
Wiener Medizinische Wochenschrift 137(9): 193-196
1987
ISSN/ISBN: 0043-5341 PMID: 3111101 Document Number: 291176
Poly (ADP-ribose) synthesis and DNA synthesis after medication of dexamethasone was determined in 16 cases. Poly (ADP-ribose) synthesis in peripheral lymphocytes decreased after low dose dexamethasone. In a second trial with double doses of dexamethasone no significant decrease of Poly (ADP-ribose) in relation to DNA synthesis could be shown. There seems to be a connection between suppression of Poly (ADP-ribose) and cell cyclus of lymphocytes, specially the S-phasis of lymphocytes. The decrease of Poly (ADP-ribose) synthesis after cortisone medication is dosis connected. Dosis, interval of dosis and over all dosis are closely related to the effect of immunosuppression of this steroidal hormone.