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Inhibitory effect of tannin on poly (ADP-ribose) glycohydrolase from human placenta

Tanuma, S.; Sakagami, H.; Endo, H.

Biochemistry International 18(4): 701-708

1989

ISSN/ISBN: 0158-5231
PMID: 2764971
Document Number: 331280
Tannin, a naturally occurring polyphenolic compound, was found to inhibit the activity of purified poly(ADP-ribose) glycohydrolase from human placenta. The inhibition was dose-dependent and half maximal with 2.8 micrograms/ml of tannin. The inhibitory effect of tannin was two and three orders of magnitude more than those of ADP-ribose and cAMP, respectively. Kinetic analysis revealed that the inhibition by tannin was competitive with respect to the substrate poly(ADP-ribose).

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