Epirubicin-induced differentiation of human neuroblastoma cells in vitro
Rocchi, P.; Ferreri, A.M.; Simone, G.; Prodi, G.
Anticancer Research 7(2): 247-250
1987
ISSN/ISBN: 0250-7005 PMID: 3473974 Document Number: 290959
On the basis that inhibition of cell proliferation may play a role in the differentiation process, we have studied the effect of the antineoplastic drug epirubicin, an antibiotic of the anthracycline group, on human neuroblastoma cell lines SK-N-MC, SK-N-SH, SJ-N-KP, TS12 and AF8. Epirubicin induced morphological and biochemical differentiation in these cultured cell lines; treatment with it stimulated the outgrowth of neurites and increased acetylcholinesterase activity.