Immunopathogenesis and immunological parameters of human semen
Merino, G.
Archives of Std/HIV Research 8(3-4): 215-219
1994
ISSN/ISBN: 1071-0906 PMID: 12288975 Document Number: 289792
The formation of antibodies to human sperm may be one possible reason for demonstrated infertility in some women. Women with antisperm antibodies have also been found to possess sperm agglutinins that immobilize spermatozoa. This report discusses antisperm antibodies and autoimmunity parameters in human sperm and what, if any, relationship might exist to HIV-positive men. The predominant immunoglobulins (Ig) formed are IgA, IgG, and IgM. IgM levels are normally elevated in sera of HIV-positive patients. Three types of methods have been used to detect antisperm antibodies: 1) those that cause sperm agglutination; 2) those that cause sperm immobilization; and 3) those that detect sperm-specific antibodies. Sperm plasma membrane antigen can be recognized by antisera. This recognition could lead to the identification of sperm antibodies particular to HIV infections. This is possible, but difficult, because HIV is an intracellular agent that prevents a classic antibody reaction, which in turn could lead to a positive identification and possible HIV neutralization.