Is Time-Interval Between Mini-Pill Ingestion and Breastfeeding Essential?
Toddywalla, V.S.; Patel, S.B.; Betrabet, S.S.; Kulkarni, R.D.; Saxena, B.N.
Contraception 51(3): 193-195
1995
ISSN/ISBN: 0010-7824 PMID: 7621687 DOI: 10.1016/0010-7824(95)00015-3Document Number: 289322
A study was conducted on four alternate days over an eight-day period in a group of 12 healthy, 20-35 year old exclusively breast feeding women who were interested in weaning their infants. On each study day the women ingested 150 mu-g levonorgestrel. Maternal blood and milk samples were collected at 2, 4, 6, and 8 hr intervals after LNG ingestion on the 1st, 3rd, 5th, and 8th day. A time-dependent decrease in maternal serum and increase in breast milk levels of LNG were observed. Maintaining a time interval between mini-pill intake and breastfeeding results in higher levels of LNG in breast milk, thereby exposing the infant to a bolus of LNG in a "single-delayed" feed.