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Potential antitumor agents. II. Lappin intramolecular cyclization of diethyl 3-carbazolylaminomethylenemalonate: a structure assignment

Corelli, F.; Massa, S.; Stefancich, G.; Artico, M.; Silvestri, R.

Il Farmaco; Edizione Scientifica 42(9): 641-647

1987

ISSN/ISBN: 0430-0920
PMID: 3691789
Document Number: 288887
Diethyl 3-carbazolylaminomethylenemalonate undergoes Lappin cyclization giving 2-carbethoxy-1-oxo-1,4-dihydro-7H-pyrido[2,3-c]carbazole. Formation of an angular pyridocarbazole derivative is consistent with the Markwald rule. The synthesis of 4-ethyl derivatives of the above pyridocarbazole and its 8,9,10,11-tetrahydro derivative is also reported as a goal to potential indoloquinolone antitumoral agents.

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