Comparative study of the modification of blood, blood coagulation, cardiovascular circulation by 3% modified, fluid gelatins and 6% low-molecular weight hydroxyethyl starch
Hopf, H.B.; Siepmann, H.P.
Infusionstherapie und Klinische Ernahrung 14(Suppl 2): 31-35
1987
ISSN/ISBN: 0378-0791 PMID: 2439456 Document Number: 286900
A randomized, comparative study with 3% modified fluid gelatine and 6% low molecular hydroxyethylstarch has been made on 87 patients of an intensive care unit. Both plasma substitutes were well compatible to the patients. The erythrocyte sedimentation rate was accelerated significantly by both plasma substitutes. This effect was at a maximum after 24 h and in the gelatine group it was percental about three times stronger, referred to the base line level in this group. In the hydroxyethylstarch group after 12 h the thrombocyte cell number decreased about 10.3%, referred to the base line, in the gelatine group the decrease was only 1.5% at the same time. At the chemical parameters there were no more differences between the two substitutes. Both plasma substitutes showed a mean effect of 4 h on plasma volume, referred to the changes of central venous pressure. The gelatine substitute showed a significant rise in blood pressure after end of infusion, the hydroxyethylstarch substitute did not. Both substitutes showed a rise in diuresis with a delay of 1 h. There were no differences between both solutions in the diuretic effect after infusion.