Comparative study of the effect of 3-carboxy-beta-carboline methylamide and diazepam on rat behavior
Barsegian, G.G.; Pliashkevich, I.G.; Demushkin, V.P.
Biulleten' Eksperimental'noi Biologii i Meditsiny 104(11): 579-582
1987
ISSN/ISBN: 0365-9615 PMID: 3676494 Document Number: 286677
The effects of benzodiazepine receptor agonist, diazepam, and inverse agonist, FG 7142, were examined. Strong antagonism between FG 7142 (10 mg/kg) and diazepam (1 mg/kg) activity was revealed in the open field test. On the other hand, both FG 7142 and diazepam inhibited isolation-induced intraspecies aggressive behaviour of rats. FG 7142 also reduced interspecies aggression of mouse-killing rats. The findings suggest that both diazepam and FG 7142 have antiaggressive properties in the isolation-induced aggression model, which are mediated by benzodiazepine receptors of the central nervous system.