Top Abstract Purchase Related
Home
>
Node
>
Subnode

The comparative effect of melatonin and diazepam on shifts in the anxiety-phobia status of rats evoked by damage to the amygdala

Arushanian, E.B.; Chernysheva, E.M.

Eksperimental'naia i Klinicheskaia Farmakologiia 60(1): 7-9

1997

ISSN/ISBN: 0869-2092
PMID: 9162293
Document Number: 478150
Disorders develop in the emotional sphere in the form of increased anxiety and fear in amygdalectomized rats. The pineal hormone melatonin and diazepam (in an equal dose of 0.1 mg/kg) alleviate the state of anxiety and fear in the animals. Despite some differences in behavioral activity, the effect of the drugs appears to be similar. This suggests that melatonin possesses anxiolytic properties which may be related to its effect on the function of the limbic structures.

Document emailed within 1 workday
Secure & encrypted payments

Golda, V.; Petr, R. 1990: Animal model of anxiety: effect of chronic diazepam treatment in the genetically hypertensive rats of Koletsky type and in the rats of Wistar strain Sbornik Vedeckych Praci Lekarske Fakulty Karlovy University V Hradci Kralove 33(2): 165-175
Griffin, L.; Youssef, N.A. 2017: Phobia with hallucinations and PTSD: can amygdala dysfunction be a common unified lesion in the RDoC sense? Annals of Clinical Psychiatry: Official Journal of the American Academy of Clinical Psychiatrists 29(3): 207-208
Buldakova, S.L.; Skrebitskiĭ, V.G.; Chepelev, V.M. 1982: Effect of diazepam on the evoked response of the neurons in hippocampal slices Biulleten' Eksperimental'noi Biologii i Meditsiny 94(8): 43-45
Równiak, M.; Szteyn, S.ła.; Robak, A. 2003: A comparative study of the mammalian amygdala: a Golgi study of the basolateral amygdala Folia Morphologica 62(4): 331-339
Yang, X.M.; Luo, Z.P.; Zhou, J.H. 1988: Potentiating effect of clonidine on the anxiolytic action of diazepam in a rat social interaction model of anxiety Zhongguo Yao Li Xue Bao 9(2): 104-107
Wurpel, J.N.; Hirt, P.C.; Bidanset, J.H. 1993: Amygdala kindling in immature rats: proconvulsant effect of the organophosphate insecticide-chlorpyrifos Neurotoxicology 14(4): 429-436
Liao, J.X.; Wang, L.; Zuo, C.H. 1997: Autoradiography of NMDA receptors in amygdala-kindled rats with tolerance to and dependence on the anticonvulsant effect of clonazepam Yao Xue Xue Bao 32(2): 137-139
Akopian, N.S.; Baklavadzhian, O.G.; Sarkisian, N.V. 1993: Effect of hypothalamus and amygdala on the impulse activity of neurons of the medullary respiratory center in rats during hypoxia Aviakosmicheskaia i Ekologicheskaia Meditsina 27(3): 33-37
Infante, C.; Cartier, L.; Motles, E. 2002: Comparative study of the epileptogenic effect of kainic acid injected into the cerebral cortex, hippocampus and amygdala in adult cats chronically implanted Archives Italiennes de Biologie 140(1): 31-40
Golda, V. 1991: Effect of diazepam in circadian rhythm of activity and in novelty induced hyperactivity in the genetically hypertensive rats of Koletsky type and in the normotensive rats of Wistar strain Sbornik Vedeckych Praci Lekarske Fakulty Karlovy University V Hradci Kralove 34(3): 255-264
Dolzhich, G.I.; Goriun, G.G. 1986: Comparative morphologic evaluation of the effect of various types of ultrasonic oscillatory shifts in glaucoma surgery Vestnik Oftalmologii 102(5): 35-39
Lino, A.; Rusconi, A.C.; Zisa, G. 1994: Anxiety and ++phobia in dental patients. Recent findings regarding the "fear of the dentist" La Clinica Terapeutica 144(1): 55-62
Matla, J.; Langwiński, R. 1984: Effect of diazepam on various effects of morphine use in mice and rats Annales Universitatis Mariae Curie-Sklodowska. Sectio D: Medicina 39: 125-133
Golda, V.; Petr, R. 1990: Animal model of anxiety: the effect of chronic dihydroergotoxine treatment in the genetically hypertensive rats of Koletsky type and in the rats of Wistar strain Sbornik Vedeckych Praci Lekarske Fakulty Karlovy University V Hradci Kralove 33(2): 177-189
Oliĭnyk, E.V.; Meshchyshen, I.F. 2004: Effect of melatonin and radiation on pro- and antioxidant state of the liver and blood of rats Ukrains'kyi Biokhimichnyi Zhurnal 76(5): 144-147
Barsegian, G.G.; Pliashkevich, I.G.; Demushkin, V.P. 1987: Comparative study of the effect of 3-carboxy-beta-carboline methylamide and diazepam on rat behavior Biulleten' Eksperimental'noi Biologii i Meditsiny 104(11): 579-582
Golda, V.; Petr, R. 1990: Animal model of anxiety: the effect of chronic bromocriptine treatment in the genetically hypertensive rats of Koletsky type and in the normotensive rats of Wistar strain Sbornik Vedeckych Praci Lekarske Fakulty Karlovy University V Hradci Kralove 33(2): 153-163
Kaya, H.; Oral, B.; Ozgüner, F.; Tahan, V.; Babar, Y.; Delibaş, N. 1999: The effect of melatonin application on lipid peroxidation during cyclophosphamide therapy in female rats Zentralblatt für Gynakologie 121(10): 499-502
Damian, E.; Ianăş, O.; Bădescu, I. 1980: The effect of pineal polypeptides and melatonin on serum and pituitary LH and FSH in adult male rats Endocrinologie 18(3): 155-159
Shannon, H.E.; Herling, S. 1983: Discriminative stimulus effects of diazepam in rats: evidence for a maximal effect Journal of Pharmacology and Experimental Therapeutics 227(1): 160-166