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Human immunodeficiency virus type 1 seroconversion in women with genital ulcers

Plourde, P.J.; Pepin, J.; Agoki, E.; Ronald, A.R.; Ombette, J.; Tyndall, M.; Cheang, M.; Ndinya-Achola, J.O.; D'Costa, L.J.; Plummer, F.A.

Journal of Infectious Diseases 170(2): 313-317

1994

ISSN/ISBN: 0022-1899
PMID: 8035016
DOI: 10.1093/infdis/170.2.313
Document Number: 286281
Genital ulcers are implicated as a risk factor enhancing susceptibility to human immunodeficiency virus type 1 (HIV-1) infection. A prospective study to determine the incidence of and risk factors associated with acquisition of HIV-1 in women with genital ulcers was done. HIV-1-seronegative women with genital ulcers attending a clinic for sexually transmitted diseases in Nairobi were followed to HIV-1 seroconversion over a 6-month period. Of 81 women, 10 seroconverted to HIV-1. The crude 6-month incidence of HIV-1 infection was 12%. Risk factors associated with seroconversion included cervical ectopy (rate ratio (RR), 4.9; 95% confidence interval (CI), 1.5-15.6) and pelvic inflammatory disease (RR, 6.3; 95% CI, 1.9-20.4). Thus, cervical ectopy and pelvic inflammatory disease may increase susceptibility to HIV-1 in women with genital ulcers.

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